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This chapter explains the multifaceted role of Chief Information Officers (CIOs) in the realm of E-Business. CIOs are the linchpin ensuring that technology strategy not only complements but also enhances, organizational objectives. They strategically align investments and drive technological adoptions while managing the inherent risks, particularly cybersecurity threats. Furthermore, they play a pivotal role in spearheading innovation, fostering collaboration, and endorsing agility within the organization. Readers will gain insights into the imperative of balancing technology with business goals, understanding the intricacies of technology risk management, and the importance of cultivating a culture of innovation and adaptability in the ever-evolving E-Business landscape.