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Integrating various IT strategy frameworks and methodologies can offer businesses a tailored, comprehensive approach to address their unique challenges and objectives. This integration combines the strengths of different methodologies, allowing a holistic IT strategy that includes governance, service management, and agile practices. However, while there are significant advantages such as enhanced agility and resource optimization, there are challenges, including managing complexity and ensuring organizational alignment. This chapter discusses the benefits and obstacles of such integration, providing guidance on effective strategies for implementation. By reading further, organizations will gain insights on how to effectively combine frameworks, ensuring consistency, stakeholder alignment, and long-term value creation in an ever-evolving digital landscape.