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The chapter explores the vital role IT leaders play in fostering innovation within organizations. It highlights how they act as catalysts, change agents, and risk managers, while also focusing on creating a culture that supports innovation. By embracing disruptive technologies and leading by example, IT leaders can significantly impact their organization’s success in the digital age. Real-world examples from companies like Target, Netflix, Google, LEGO, Cleveland Clinic, Philips Hue, and DBS Bank are provided to illustrate these principles.