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The chapter explores the critical role of IT leadership during mergers and acquisitions (M&A). It emphasizes the importance of strategic planning, security, communication, and consideration of both the technical and human elements during IT systems integration. The content is illustrated with real-world case studies such as the integration of American Airlines and US Airways, Microsoft’s acquisition of GitHub, and Tesla’s acquisition of SolarCity. Insight into best practices and common pitfalls provide valuable guidelines for navigating the complex process of IT integration during M&A.