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This chapter delves into the fundamental aspects of IT project and program management, emphasizing their pivotal role in aligning IT initiatives with business goals, optimizing resource usage, and handling risks. It covers popular project management methodologies, including Agile, Waterfall, Scrum, and PRINCE2, and explores best practices for program management. Real-world examples and case studies such as London Heathrow Airport’s Terminal 5 Project, IBM’s Project Big Green, and Procter & Gamble’s Global Business Services Transformation offer practical insights into successful project and program management.