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Business-IT alignment is the synergy achieved when a company’s IT initiatives align seamlessly with its strategic goals, and in today’s digital age, this alignment is vital for innovation, efficiency, and maintaining competitiveness. This chapter dives into the evolution of IT from a back-end supportive function to a core strategic partner, emphasizing how IT governance provides the necessary framework for this alignment. By examining renowned companies such as Netflix, LEGO, British Airways, and FedEx, readers will glean insights into successful alignment strategies that harness technology to drive business objectives. Delve deeper to uncover strategies, frameworks, and leadership principles to bolster your organization’s alignment journey.