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IT governance plays an integral role in aligning IT activities with an organization’s strategic goals and establishing clear roles, responsibilities, and decision-making processes to optimize IT investments. While large organizations focus on centralized or decentralized structures, IT governance committees, and managing transformations, small and medium-sized enterprises (SMEs) often adopt a more simplified approach tailored to their size and resources. This chapter examines the significance of IT governance across varying organizational sizes, highlighting best practices, key considerations, and real-world examples. Read on to understand the intricacies of IT governance, ensuring that your organization can harness technology’s potential effectively and set a trajectory for long-term success.